Dimethylglycine (or DMG for short) is a derivative of the amino acid glycine — a building block essential for creating protein. It is present in the cells of all plants. Dimethylglycine (DMG) is an amino acid found naturally in plant and animal cells and in many foods such as beans, cereal grains, and liver. It is used to improve energy, boost the immune system, and to manage seizures and autism. There are some positive reports of DMG efficacy on the immune system. Tips and Overview Patients and Families. Much of the current interest in megavitamin B6 therapy for autistic children stems from the publication of our report (Autism Research Institute) in the American Journal of Psychiatry in 1978.This double-blind evaluation of B6, like our 1973 study, provided experimental evidence that B6 was helpful. See, when DMG is digested it somehow reduces the bodies Folic acid level, which in turn can cause hyperactivity. SO the Folic acid is added to negate that. The B12 aids in the digestion/absorption of the DMG and Folic acid.
Biomedical treatmentrelies heavily on methylation biochemistry for its success. Some of you may be familiar with methylation and the role it plays in autism, ADHD and Down Syndrome. For some, methylation may be a new term. The important thing to know is that if you have a child with suspected or diagnosed autism spectrum disorder, you need to be helping to repair their methylation cycle in as many ways as possible. Are you currently giving your child B12 injections? If so, you are supporting methylation but there a dozens of ways for you to add to the methyl B12 injection benefit. So come take a roller coaster ride with me through the ups and downs and loopty loops of methylation.
What is methylation biochemistry, you ask?
Women take folic acid when they are pregnant because the folate cycle is responsible for making all the cells in the body. Women who have folate cycle impairments are 4.7 times as likely to have a child diagnosed with ASD. Before you cringe (mom), these methylation and folate cycle issues can be caused by epigenetic damage. So, if your grandmother smoked or ate tuna filled with mercury, your child could have an increased risk of a neurodevelopmental disorder. Back to methylation…
Directly next to the folate cycle is the methylation cycle. Ninety percent of children diagnosed with autism have demonstrated methylation impairment. Metals like lead and mercury can further damage the body’s ability to methylate DNA. Methylation IS the process of development. When babies are conceived, they are not methylated. Healthy methylation = healthy, neurotypical children. Impaired methylation leads to increased risk of tongue ties, birth defects, speech delay, autism, ADHD etc.
Methylation is needed for:
- RNA and DNA (genetic material responsible for every function in the body)
- Immune system regulation
- Detoxification of heavy metals and other harmful substances
- Making GLUTATHIONE (the body’s main detoxification enzyme responsible for removing mercury, lead, cadmium, arsenic, nickel, tin, aluminum and antimony)
- Production and function of proteins
- Regulating inflammation
- Making neurotransmitters like serotonin and dopamine
- Producing melatonin, CoQ10, carnitine, creatine, and choline
Now that we understand the importance of methylation, let’s look at how you can (AND NEED) to support your child. Download mac fonts.
- Has your child benefitted from B12 injections? In my practice, 92% of children respond to injection therapy. Research from the Arkansas Children’s Research Institute has shown that methyl B12, when injected helps to support methylation and production of glutathione. If your child has benefited, make sure to read through the other supports listed below. If your child has NOT benefited after trying B12 injections, the three most common reasons are elevated levels of heavy metals, the wrong diet and/or low level viral infection.
Diet
- The diet that best supports the methylation cycle is the “paleo” diet. Meat, vegetables, fruit, nuts and seeds. Meat should be hormone and antibiotic free. Vegetables and fruit should be organic whenever possible. The methylation cycle helps the body detoxify harmful chemicals like PCBs found in pesticides. Reducing the body’s overall toxic load help to repair the methylation cycle. Grains are fortified with synthetic folic acid. Folic acid sounds important to the folate cycle, doesn’t it? The problem is that children diagnosed with autism often (40-70% of the time) have trouble converting synthetic folic acid to methyl folate which is needed to “spin” the methylation wheel and help to make glutathione.
- Most biomedical parents would agree that one of the hardest parts of treatment is “the diet”. Take population of kids who have sensory issues around food, and add in dysregulated dopamine which contributes to food addiction. Now try to remove foods that children are using to help calm an overly stressed brain. The problem with carbohydrates, dairy and sugar are that they help kids feel good, but it is short term and short lived… leading to the next craving cycle. It is crucial to interrupt this cycle that is toxic to the brain. Many studies have shown that carbohydrate restriction helps improve brain function. Ask Dr. Perlmutter, author of Grain Brain, if you don’t believe me! So… why NO GRAINS!!!!???? Grains are fortified with synthetic folic acid which dramatically slows down the brains ability to heal from damage or inflammation.
Glutathione
- Glutathione is the body’s master antioxidant. Depletion of up to 80% has been linked to ASD. One of the most important jobs of the methylation cycle is to produce glutathione which detoxifies metals, chemicals and hormones. Glutathione is needed to protect the brain from toxicity and is, in fact, the rate limiting step to a child’s development. A child’s brain can only develop as far as their glutathione will take them.
Methyl folate and folinic acid
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- If you picture the folate cycle, snuggled up to the methylation cycle, you can imagine that any influx of methyl donors could be beneficial. Adding additional methyl folate to a child’s treatment protocol helps in a number of different ways. The methyl group from methyl folate is given to SAMe, whose job it is to deliver methyl to 200 essential pathways in the body. Methyl folate is also very important in treating children who have been diagnosed with Cerebral Folate Deficiency, a cause of autism spectrum disorder and seizures.
SAMe
- SAMe is what I like to call a worker bee. After receiving methyl donors, SAMe delivers methyl to 200 pathways in the body including ones needed to make carnitine, creatine and phosphotidylcholine.Low carnitine levels have been identified in children diagnosed with autism. Carnitine supplementation improves delivery of omega 3 & 6 fatty acids needed to support language, social and cognitive development. Phosphatidylcholine is important in cell membrane health and repair. Toxins can damage the cell membrane, which contributes to inflammation as it is broken down. Repair of the cell membrane is an important part of improving sensory issues and motor planning issues in children with autism, ADHD and sensory integration disorder
DMG and TMG
- Dimethylglycine (DMG) and trimethylglycine (TMG) donate methyl groups to the methylation cycle. TMG is needed to recycle homocysteine and help produce SAMe. If DMG is beneficial for your child, note that long term use will slow methylation. After a period of DMG supplementation, it is important to start using TMG and SAMe to optimize this vital cycle needed for neurological health.
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N,N-Dimethylglycine (short: DMG) is an intermediate of choline metabolism. Betaine (metabolized from choline and is a metabolic precursor to dimethylglycine) donates a methyl group to homocysteine to form methionine [1]. By this removal of one methyl group from betaine, dimethylglycine is formed [1]. DMG is often sold commercially as hydrochloride salt (dimethylglycine HCL).
Dimethylglycine’s Effects on Athletic Performance
Dimethylglycine has been claimed to be an athletic performance enhancer and can be found in various sports supplements. Since dimethylglycine donates methyl groups to transmethylation process it is claimed to improved energy usage. Therefore, it is often marketed and sold as an energiser.
The interest in dimethylglycine arose from a report indicating that N,N-Dimethylglycine reduces lactic acid concentration in blood in response to surgical stress in animals [2]. Further human and animal studies yielded inconsistent results. A study on dimethylglycine-treated horses by Moffit et al. [3] reported lower plasma lactate concentrations after treadmill exercise. However, this study raised doubts about dimethylglycines effectiveness due to an unbalanced design used. Rose et al. [4] found no differences in muscle lactate concentrations in horses treated with dimethylglycine and horses receiving placebo.
In trained athletes, Pipes [5] noted a 23,6% increase in time to fatigue after DMG supplementation. In contrast, Gray and Larry [6] reported no significant changes in short-term maximal treadmill performance between the group receiving pangamic acid (calcium gluconate and N, N-Dimethylglycine) and control. No improvements in aerobic and anaerobic performance were also reported when 400 mg of DMG per/kg of body weight was administered to elite basketball players [7]. DMG also failed to improve maximal treadmill exercise to exhaustion in well-trained college women [8]. Authors of this study concluded that there is no evidence to recommend DMG as an ergogenic aid to endurance athletes.
Dimethylglycine supplementation seems to have little to no effect on athletic performance besides evidence available is limited and conflicting. More well-researched clinical trials should be done before any definitive conclusions can be made.
Other Dimethylglycine Uses
Treatment of Autism
Dmg And Autism
N,N-dimethylglycine has also been reported to be beneficial in children with autism [9]. Kern et al. [9] reported that some children seem to respond positively to the dimethylglycine supplementation but overall behavioural assessments were not significantly different from children receiving placebo. Same was reported by Bolman and assistants [10], however, the weakness of this study is low dosage used in a small number of children. According to available evidence, subjects treated with DMG show little to no difference compared to untreated subjects for treatment of autism spectrum disorder [11].
Immunostimulant Properties
DMG may improve body’s immune system as reported by Graber and others [12]. Results of their study suggest that dimethylglycine supplementation improves humoral as well as cell-mediated immune responses in humans [12].
Side Effects
Dmg Dimethylglycine Benefits
Mac cleaner frys. Very large doses up to 200 mg/kg given to animal models caused no adverse events [7]. This is not surprising as DMG is a natural metabolite which doesn’t build up in the body.
(Other common names: Pangamic Acid, Vitamin B15, Pangamate) Download mac mavericks dmg 2017.
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References
- Friesen, Russell W., et al. “Relationship of DMG, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants.” The Journal of nutrition 137.12 (2007): 2641-2646.
- Meduski, J. W., et al. 1980. “Decrease of lactic acid concentration in blood of animals given N,N-dimethylglycine.” Presented at Pacific Slope Biomedical Conference, Univ. of California, San Diego, (1980) 7-9.
- Moffitt, P., et al. “Venous lactic acid levels in exercising horses fed N, N-DMG.” Proceedings of the 9th Equine Nutrition and physiology Symposium, E., Lansing, Michigan. 1985.
- Rose, R. J., et al. “Effects of N, N-DMG on cardiorespiratory function and lactate production in thoroughbred horses performing incremental treadmill exercise.” Veterinary Record 125.10 (1989): 268-271.
- Pipes, T. V. “The effects of pangamic acid on performance in trained athletes.” Med. Sci. Sports Exercise (1980) 12:98
- Gray, Michael E., and Larry W. Titlow. “The effect of pangamic acid on maximal treadmill performance.” Medicine and science in sports and exercise 14.6 (1982): 424.
- Reza, Attarzadeh Seyed, et al. “The effect of DMG administration on Biochemical Blood Parameters in Youth elite Basketball Players.” (2013) 55-59.
- Brown, H., L. M. Reimnitz, and A. J. Koch. “No Effect of DMG on Maximal Aerobic Power.” The Journal of Strength & Conditioning Research 25 (2011): S109-S110.
- Kern, Janet K., et al. “Effectiveness of N, N-DMGin autism and pervasive developmental disorder.” Journal of Child Neurology 16.3 (2001): 169-173.
- Bolman, William M., and John A. Richmond. “A double-blind, placebo-controlled, crossover pilot trial of low dose DMGin patients with autistic disorder.” Journal of autism and developmental disorders 29.3 (1999): 191-194.
- Rossignol, Daniel A. “Novel and emerging treatments for autism spectrum disorders: a systematic review.” Ann Clin Psychiatry 21.4 (2009): 213-36.
- Graber, Charles D., et al. “Immunomodulating properties of DMGin humans.” Journal of Infectious Diseases 143.1 (1981): 101-105.